Assistant/Associate/Full Professor (T/TT) - Associate Director of the Diabetes Diagnostic Laboratory
University of Missouri - Columbia (MU)
Columbia, MO
Full-time
Education
Posted on April 25, 2024
Job Description
TheDepartment of Pathology and Anatomical Sciencesat the University of Missouri is seeking outstanding candidates for the position of Associate Director of theDiabetes Diagnostic Laboratory(DDL). Primary responsibilities will include coordination of the clinical and research efforts in this laboratory and participation as an investigator on all grants and contracts for which the Director,Dr. Randie Little, is the current PI. The candidate must have some experience in both clinical and research areas and have respect for both areas of work.This position is expected to transition to Director on retirement of the existing director.
About the DDL
The DDL is nationally recognized for our HbA1c testing and expertise, leading us to the forefront of efforts to standardize and improve the quality of HbA1c testing. Our laboratory is equipped with state-of-the-art diabetes-related testing for both research and clinical trials.
Our facility has served as a reference laboratory for the groundbreaking study, the Diabetes Control and Complications Trial (DCCT), operates as the central diabetes testing laboratory for theNational Health and Nutrition Examination Surveys(NHANES), and functions as the administrative core of theNational Glycohemoglobin Standardization Program(NGSP), an international program for standardization of HbA1c assays, which are important tests used to assess glycemic control in patients with diabetes.
The Clinical Role
A basic knowledge of clinical laboratory regulatory requirements such as Clinical Laboratory Improvement Amendments (CLIA) and College of American Pathologists (CAP) is important, as well as an understanding of these specific diabetes test methodologies. Experience in managing a clinical laboratory is helpful but not mandatory. The clinical portion of the laboratory includes, but is not limited to:
- Measurements of HbA1c (by both ion-exchange and boronate affinity HPLC)
- Insulin and c-peptide analyses
- Patient result reporting
The research portion of the laboratory considerably overlaps with the clinical portion. The DDL Laboratory Director serves as the NGSP Network Coordinator. The NGSP maintains a laboratory network with reference method results that are based on landmark clinical trial data. The program certifies manufacturer assay methods for HbA1c and certifies and monitors laboratories doing large studies and clinical trials where measurement of HbA1c is a key variable. Proficiency testing, primarily through the CAP, is used to evaluate progress toward improved comparability of results among laboratories. The NGSP network assigns values to the accuracy-based CAP HbA1c survey.
Current research projects include:
- Examination of stability of HbA1c and interference (e.g. from Hb variants) with different assay methods
- Standardization of c-peptide assays (in progress)
- The c-peptide program includes the use of single donor and pooled serum specimens for use by manufacturers in the calibration of their assays.
- Operates a LS/MS reference method for c-peptide in coordination with the National Metrology Institute of Japan which also has a C-peptide reference method.
- Traceability scheme, including a reference method and certified reference materials has been proposed along with next steps for implementation
- Evaluation of glycated albumin for use in patients with renal failure and determination of glycation rates of common variant hemoglobins
Minimum Qualifications: PhD, MD, or DO
Application Materials
Be prepared to upload a CV.
Community Information
Columbia, Mo., is known as an ideal college town, combining small-town comforts, community spirit and low cost of living with big-city culture, activities and resources. Home to nationally renowned public schools and other colleges and educational centers, Columbia is packed with restaurants and entertainment venues and hosts more than a dozen annual cultural festivals.
Benefit Eligibility
This position is eligible for University benefits. The University offers a comprehensive benefits package, including medical, dental and vision plans, retirement, and educational fee discounts. For additional information on University benefits, please visit the Faculty & Staff Benefits website athttp://www.umsystem.edu/totalrewards/benefits
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In your application materials, please discuss your experiences and expertise that support these values and enrich our missions of teaching, research and engagement.
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